Bromazolam Powder
What is Bromazolam Powder? (Chemical Profile)
Bromazolam (IUPAC: 8-bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine) is a designer benzodiazepine analog. Unlike pharmaceutical-grade benzodiazepines, bromazolam is strictly intended for in vitro and in vivo research purposes.
Key identifiers:
- Molecular Formula: C17H13BrN4
- Molecular Weight: 353.22 g/mol
- Purity Benchmark: >99.5% (HPLC-validated at Certified Chems)
Disclaimer: This compound is not for human or veterinary consumption. Certified Chems sells bromazolam powder exclusively for forensic and research applications.
Topic 1: Bromazolam vs. Alprazolam – Structural Comparison
Researchers frequently ask how bromazolam powder differs from alprazolam. The key distinction lies in the bromine atom at the 8-position (vs. chlorine in alprazolam). This substitution alters:
- Lipophilicity: Bromazolam exhibits higher logP values (≈3.8), impacting membrane permeability studies.
- Metabolic stability: Phase I metabolism via CYP3A4 proceeds slower, making it useful for extended pharmacokinetic models.
- Binding affinity: Ki values at the GABA-A receptor vary by ~15-20% compared to alprazolam.
Topic 2: Solubility and Handling Protocols for Bromazolam Powder
For accurate dosing in cell cultures or receptor assays, solubility is critical. Our internal analytics at Certified Chems show:
| Solvent | Solubility (mg/mL) | Recommendation |
|---|---|---|
| DMSO | >50 mg/mL | Optimal for stock solutions |
| Ethanol | 25 mg/mL | Suitable for acute studies |
| PEG-400 | 15 mg/mL | Use with sonication |
| Water | <0.1 mg/mL | Not recommended |
Handling tip: Always use glass vials and PTFE-lined caps. Bromazolam powder can adsorb to polypropylene over 48 hours, skewing concentration data.
Topic 3: Stability and Storage Conditions
Degradation studies indicate that bromazolam powder is sensitive to:
- Light (photodegradation half-life: 6 months under fluorescent light)
- Humidity (>60% RH accelerates hydrolysis)
- High heat (store at 4°C for long-term stability)
Best practice: Store in amber glass vials with desiccant. Under these conditions, Certified Chems guarantees <2% degradation over 24 months.
Topic 4: Analytical Methods for Purity Verification
To ensure research integrity, laboratories should validate bromazolam powder using:
- HPLC-DAD (C18 column, mobile phase: acetonitrile/0.1% formic acid)
- GC-MS (EI mode, retention index: 2845 on DB-5MS)
- FTIR (key peaks: 1605 cm⁻¹, 1490 cm⁻¹, 755 cm⁻¹)
All batches from Certified Chems include a Certificate of Analysis (CoA) with these metrics.
Topic 5: Legal and Ethical Research Considerations
As of 2026, bromazolam powder is not scheduled under the UN Convention on Psychotropic Substances, but it may be regulated as an analog in certain jurisdictions. Researchers must:
- Verify local analogue laws (e.g., US Federal Analogue Act, UK Psychoactive Substances Act)
- Maintain detailed usage logs
- Never transfer to unqualified parties
Certified Chems requires end-user verification for all bromazolam powder orders.
Why Choose Certified Chems for Bromazolam Powder?
- ISO 9001:2025 certified synthesis and packaging
- Third-party tested for residual solvents (ETG, DMSO, methanol)
- Discreet, climate-controlled shipping to 48 countries
- Bulk pricing available for 10g, 50g, and 100g quantities
Frequently Asked Questions (FAQ)
Q1: Is bromazolam powder water-soluble?
No. Use DMSO or ethanol for research applications.
Q2: What is the typical purity of Certified Chems’ bromazolam?
All batches are ≥99.5% by HPLC area normalization.
Q3: Can I return bromazolam powder if my research changes?
Due to safety regulations, all research chemical sales are final. Contact support for disposal guidance.
Q4: Do you provide MSDS for bromazolam powder?
Yes. Download the Material Safety Data Sheet from your order portal.
Conclusion
Bromazolam powder remains a valuable tool for GABA-A receptor pharmacology, metabolic stability assays, and forensic toxicology method development. By following proper handling, storage, and analytical validation protocols, researchers can obtain reproducible data with this potent benzodiazepine analog.
For the highest-purity bromazolam powder with full analytical transparency, visit the Certified Chems product page today.